Preheat oven to 350 degrees Fahrenheit. Lightly butter a 9x13-inch casserole dish.
Shred all cheeses and combine in a large bowl. Set aside.
Bring a large pot of generously salted water to a boil. Cook pasta according to package directions until just al dente. Drain and set aside.
In a small bowl, combine garlic powder, paprika, salt, and black pepper.
Melt butter in a large skillet over medium heat. Add half of the seasoning mixture and cook for 30 seconds, stirring constantly.
Whisk in flour to create a roux. Cook for 1 to 2 minutes, stirring often.
Slowly whisk in evaporated milk a little at a time. Gradually whisk in heavy cream until smooth and fully combined. Add remaining seasoning mixture and Dijon mustard. Cook, whisking often, until sauce thickens.
Add half of the shredded cheese mixture one handful at a time, whisking until fully melted before adding more cheese.
In a large bowl, combine cooked pasta with the cheese sauce.
Spread half of the pasta mixture into the prepared casserole dish. Sprinkle with half of the remaining shredded cheese. Add the rest of the pasta mixture and top with the remaining cheese.
Bake for 25 to 30 minutes, until hot and bubbly.
Turn oven to broil and cook for an additional 2 minutes, or until the top is golden brown.