Preheat oven to 350 degrees F. Grease a 9x13 baking dish with cooking spray
Place chicken breast in baking dish in a single layer. Lightly salt and pepper. Spread mushrooms on top
In a medium size bowl mix soups, sour cream, onion powder,garlic powder and marsala wine. Then pour over top of chicken and make sure it is spread evenly.
Bake on middle rack, uncovered, for approximately 45 mins.- 1 hour, until chicken breast is cooked thoroughly
Serve with noodles, rice, potatoes or your favorite veggies!